Protein Scientist Resume Samples

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I Schumm

Isabella

Schumm

942 Brakus Radial

Detroit

+1 (555) 223 4483

942 Brakus Radial

Detroit

Phone

p +1 (555) 223 4483

Experience Experience

Detroit, MI

Scientist, Protein Homeostasis

Detroit, MI

Harvey Inc

Detroit, MI

Scientist, Protein Homeostasis

Communicate with peers and supervisors and foster teamwork
Develop and implement relevant cell based assays to support identification, optimization, and characterization of novel chemical matter and their targets
Develop and implement cell-based assays to define SAR of novel chemical matters
Design and develop novel assays
Contributes individually as well as on cross functional teams
Well versed in fundamentals of functional area
Responsible for more complex assignments and for more than 1 project

Philadelphia, PA

Scientist, Protein Homeostasis Tcoe

Philadelphia, PA

Gleason, Yundt and Douglas

Philadelphia, PA

Scientist, Protein Homeostasis Tcoe

Design and execute experiments to define and test hypotheses for selection of tumor type and patient characteristics for particular drugs, and drug combinations, including small molecules and biologics
Develop and/or characterize pre-clinical and clinical methods for measuring pharmacodynamic effects and surrogate markers for efficacy to guide determination of dose, schedule, and priority indications in clinical trials
Design and execute biomarker and correlative components of clinical trials, including participation on trial teams, management of vendors, analysis of data, and communication with study investigators and other stakeholders
Works as an individual contributor
Potential to manage and/or coordinates workflow on projects
Provide scientific direction
Identify and recommend new technology

present

New York, NY

Flpc / Akta Protein Purification Scientist

New York, NY

Cummings, Goyette and Daniel

present

New York, NY

Flpc / Akta Protein Purification Scientist

present

Molecular cloning including: PCR, DNA digestion, ligation, and mutagenesis
Cell culture maintenance and transfections including: CHO, HEK 293, sf9, and sf21
Protein characterization including: HPLC, SDS-PAGE, native PAGE, western blot, DLS, and endotoxin assay
Participate in self-development activities and training of others
Protein purification with FPLC including affinity, ion exchange, HIC, etc
Effectively utilize standard laboratory equipment including hand pipettes, balances, pH meters, plate readers and calculators
Use and maintain equipment in a neat and orderly manner. Report any malfunction immediately to supervisor

Education Education

Bachelor’s Degree in Independence

DePaul University

Bachelor’s Degree in Independence

Skills Skills

Demonstrate ability to write peer reviewed quality work
Capability to stay focused and deliver high quality data in a timely and well organized manner
Excellent time management and organizational skills
Ability to enjoy working in a fast-paced dynamic team environment with the flexibility to adapt to changes with a positive attitude
Comprehensive knowledge of hematological malignancy
Able to write invention disclosure for patent application, technical reports, technical protocols
Developing cross-functional scientific knowledge
Strong communication skills, both written and oral
Able to design complex experiments with scientific rationale
Able to critically analyze and interpret data

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15 Protein Scientist resume templates

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Scientist for Protein & M Ab Hplc Assays Resume Examples & Samples

Bachelor’s degree or higher in Chemistry, Biochemistry or related discipline
8+ years of industrial experience in analytical development for proteins and mAbs
Experience with HPLC methods (RP-HPLC, IEC, SEC and HIC etc.)
Familiarity with a wide range of protein analytical techniques including CE, icIEF, UV-Vis spectroscopy, immunoassay (ELISA) etc. preferred

Scientist, Protein Conjugation Resume Examples & Samples

70% Research Activities including experimental planning and direct laboratory activities, relevant and necessary literature review
20% Communication with supervisor regarding experimental designs and results. Communication with members of Discovery Biology and Discovery Therapeutics Departments. Helping of team members to succeed in scientific experiments. Consultation with outside experts and collaborators
10% Report writing and record keeping

Scientist, Protein Expression Resume Examples & Samples

The individual will work as part of the Cell Biology R&D team to support ongoing projects within the Thermo Fisher product commercialization process under the Gibco™ brand
The successful candidate will possess a strong background in cell biology and cell culture with a focus on mammalian transient protein expression; protein expression in other systems (i.e. insect, yeast, bacteria) or generation of stably-expressing cell lines is a plus
Experience with scalable protein expression, from microtiter plates to bioreactors is desirable, as is experience in molecular biology for vector design, plasmid generation, amplification and purification
The candidate will require strong organizational skills to support full documentation of new product development for complex projects
Ability to multitask and maintain a results-oriented focus is essential
2-4+ years industry or academic experience
Mammalian cell culture for suspension cultures
Transient and/or stable protein expression
Molecular biology techniques including DNA cloning, vector design, plasmid preparation/purification,
Excellent time management skills and multi-tasking capabilities

Scientist, Protein Purification Cgmp Resume Examples & Samples

Ph.D. in Biotechnology, or related field with at least 2 years of laboratory experience
MS in Biotechnology, or related field with at least 3 years of industry laboratory experience
B.S/B.A. in Biotechnology, or related field with at least 5 - 8 years experience in a laboratory environment
Associates Degree/Certificate/Diploma in laboratory science with minimum of 7 years experience in a laboratory
Communicate effectively and follow detailed written and verbal instruction; ability to clearly communicate and provide mentorship to other groups and clients as necessary
Ability to peer review data to ensure data is well organized with complete documentation
Ability to interpret data, analyze trends and provide insight into potential issues and subsequent solutions
Proficient in the operations of a computer with MS-Excel, MS-Word as well as programs for multiple pieces of laboratory or manufacturing equipment
Positive attitude and ability to work well with others as a technical lead
Ability to write SOPs and reports independently
Ability to integrate timelines, devise batch records and meet milestones for successful project completion
Ability to troubleshoot and problem solve in order to initiate and execute/monitor corrective action
Ability to set deadlines and prioritize work for self, group members, and support groups/individuals involved
Ability to perform accountabilities and responsibilities independently and provide supervisor with updates as necessary
Ability to design protocols and establish project timelines with minimum Supervisor input

Protein Characterization Scientist Resume Examples & Samples

Must be highly organized and meticulous
Good written and verbal communication skills are required
Maintain laboratory notebooks in a GXP compliant manner and write technical memos
Proficient capability to understand and troubleshoot equipment, thorough 5
Knowledge of LC and LC/MS, and experience with team-based collaborations is a must
A BS in Chemical Engineering, Biological Sciences, Chemistry or Biochemistry and approximately 2-5 years of relevant experience is required
Background in the following areas is desired: LC, LC/MSn and force degradation studies
Data reporting, some ability to troubleshoot equipment is a must

Protein Scientist Resume Examples & Samples

Basic understanding of GMP and GLP procedures
Fundamental knowledge of proteins and antibodies; specific experience with protein formulation a plus
Data analysis (in Excel, Matlab, Jmp or other programs)
General wet lab skills including protein chromatographic characterization (SEC, IEC, RP), UV-visible spectroscopy and colorimetric assays
Perform analysis of samples with a variety of biochemical and biophysical assays including HPLC, ELSD, icIEF, sub-visible particle counting, osmolality, capillary electrophoresis sodium dodecyl sulfate (CE-SDS)
Troubleshoot method and instrumentation problems as needed
Develop and execute validation plans as needed
Strong organizational, scientific, computational, communication and interpersonal skills. Highly organized, team oriented, dependable, self-starter
Knowledge of protein biochemistry is required
Ability to conduct process characterization/process validation (PC/PV) experiments and pre-robustness and assay qualification studies
Basic to advance analytical knowledge in characterizing proteins with HPLC-based chromatographic techniques, electrophoresis methods, spectroscopy, and other biophysical characterization techniques
Clinical lab experience and GMP/GLP knowledge a plus
Ability to work independently and as part of a team, self-motivated, adaptable and with a positive attitude
Bachelor's or Master’s degree in biochemistry, chemistry, analytical chemistry, chemical engineering, or other related degree concentration, with 1-2 years of industrial experience or 1-2 years of academic research experience

Scientist, Protein Formulations Resume Examples & Samples

Support formulation and development of clinical protein drug candidates
Apply fundamental protein chemistry principles in identifying and resolving issues related to protein formulation and development
Sample and instrument management
Contemporaneously record all data in electronic lab notebook format
Experience in protein stability studies, protein formulation, and formulation development
Proficiency operating and troubleshooting HPLC
Working knowledge of Chromeleon for HPLC analysis
Working knowledge of Empower for UPLC analysis
Experience in subvisible particle assays (HIAC, MFI) a plus
Experience with capillary electrophoresis (CE) a plus
Ability to maintain accurate records and follow procedures is critical
Excellent project management skills, multi-tasking, and ability to elevate relevant issues to project or supervisory lead
Ability to work independently and as part of a team with internal and external clients
Ability to learn new techniques and concepts independently and by recruiting the expertise of others
Experience with drug product process development for biologics
B.S. or B.A. with 2-4 years experience or M.S. with 0-2 years experience in analytical chemistry, and degree in Chemistry, Biology, Pharmaceutical Sciences, or Life Sciences with a pharmaceutical, vaccine, or biotechnology background. Biotech/pharmaceutical industry experience strongly preferred

Scientist, Protein Expression Sciences Resume Examples & Samples

Design and construction of antibody and bispecific vectors
Recombinant cloning of antibody genes
Antibody sequence analysis, alignments to germ line and variable gene assignment
Mammalian cell transfection and Western blot characterization of recombinant proteins
Data management and presentations at departmental meetings

Scientist, Protein Homeostasis Tcoe Resume Examples & Samples

Design and execute experiments to define and test hypotheses for selection of tumor type and patient characteristics for particular drugs, and drug combinations, including small molecules and biologics
Advanced, current knowledge of oncology including disease biology and treatment approaches
Expert in cell biology including concepts and pathways, and experimental methods such as cell culture and cell-based assays, FACS, ELISAs, Westerns, gene expression, microscopy, si/shRNA/CRISPR, and techniques for analysis of epigenetic control of expression
Particular expertise and interest in protein homeostasis, hematologic malignancies especially MDS, bone marrow biology, and immunology is sought along with skill in associated assay methods (e.g. multilineage colony formation in bone marrow cultures, multicolor FACS and ex-vivo assays for T- and NK cell killing)
Draw appropriate conclusions and make recommendations on next steps
Demonstrate ability to write peer reviewed quality work
General awareness of drug discovery and development process
Lead scientist on projects
Identify and recommend new technology

Peptide / Protein Research Scientist Resume Examples & Samples

Ph.D. in Pharmacology, Protein/Peptide Chemistry, Protein Formulation and Delivery, Biochemistry or a related field in Pharmaceutical Sciences
Post-doctoral training preferred
0-2 yrs Industry (Pharma/Bioech) experience in the preclinical development of peptides/peptide fusion proteins
Experience with qualitative and/or quantitative MS methods for analysis of potential peptide based therapeutics
Experience in formulation of peptide/protein therapeutics

Scientist, Protein Conjugation Resume Examples & Samples

Hands-on experience with chemical modifications of proteins and antibodies including expression, purification and analysis
Scientific curiosity and flexibility necessary to explore novel opportunities
Commitment to creatively and aggressively pursue novel concepts and technologies
Ability to work as part of a dynamic interdisciplinary team

Protein Purification Scientist Resume Examples & Samples

Purify a variety of molecular biology enzymes and nucleic acid binding proteins to support our growing product lines
Develop scalable and robust purification processes for key enzymes that are used in company’s proprietary sequencing platforms
Complete assays measuring key enzymatic activities, as well as standard protein characterization assays
Work as part of a scientific team; participate in team meetings and initiatives to meet the goals and deliverables of time-bound projects
Other duties that may be determined by management
Continuous flow centrifugation
Depth Filtration
Ultra Scale Down techniques (USD)
Bacterial fermentation at the bench or pilot scale
Sample/Library preparations for high throughput sequencing platforms
Bioprocess Development
Biologics Process Development
Large scale microbial fermentation and purification
Process technology transfer and scale-up manufacturing
Continuous process improvements
Protein and biologics purification processes
Biopharmaceutical purification scale-up/scale-down principles
Automated/high-throughput chromatographic screening using DOE methodologies
Scale up and optimization of bacterial fermentation and purification
Protein quality control or release assays

Senior Protein Scientist Resume Examples & Samples

Molecular cloning of target genes
Protein expression in bacterial or insect cell expression systems
Protein purification using the ÄKTA purification platform
Analysis of scientific data from multiple sources e.g. cellular assays, biochemical screens and biophysics
Regular reporting of results to client project teams
Preparation of presentation materials/written proposals/work schedules to deliver business opportunities with prospective clients
Monitoring the development of scientific methods, evaluating and integration of new methods into the CRL SB team e.g. new high throughput cloning strategies
Potential to be project lead for SB focussed activities e.g. fragment screens

Protein Expression Scientist Resume Examples & Samples

Minimum BSc degree in related life science field
Extensive knowledge of protein purification, especially of challenging targets, demonstrated through the delivery of innovative solutions for drug discovery programs
Demonstrated experience in a variety of expression systems to enable expression, purification and characterisation of proteins and protein complexes
The successful candidate will have experience working in multi-disciplinary teams. Experience collaborating with scientists in external organisations would be an advantage
Broad knowledge of the target to candidate process
Track record of flexibility and enterprise thinking
Produce antigen and other proteins required for selections
Process and express hits and lead mAbs identified from selections for efficient reformatting and expression
Work with external collaborators and the high throughput expression team to ensure process fit between different stages of the antibody discovery process
Scientific impact through innovative approach to expression of proteins
Ensuring the high quality and accurate recording of scientific results, to support data integrity principles
Clear and concise presentations of results and recommendations to peers and key stakeholders

Senior Scientist, Protein Science Resume Examples & Samples

Identify any differentiating expertise required for success in the role
5+ years experience in the field of protein science with 2+ years experience in food industry or Post graduate with degree in Food Science preferably Protein Chemistry or related discipline
Excellent understanding of protein science and protein characterization
Self-starter who drives for results in an innovative, inquiring and scientifically robust manner
Excellent presentation skills (written & verbal)
Strong analytical skills - ability to interpret complex data and distil into useful and actionable information
Ability to explain complex technical issues/solutions to a non-technical audience

Research Scientist Protein Crystallography Resume Examples & Samples

Determine the atomic structures of new proteins of interest and of protein-ligand complexes using protein crystallographic methods in high throughput modes
Expert analysis of relevant data and related literature to extract important structural insights and drive drug discovery efforts with timely communication to project teams
Utilize fragment-based screening methods to guide successful hit finding activities
Provide guidance to crystallization and protein construct design efforts
Analyze literature for novel drug targets and prepare new project proposals in close collaboration with biologists and medicinal chemists
Maintain accurate and timely records of experimental results
Possibility to publish in peer-reviewed journals and present at external scientific meetings

Scientist, Transient Protein Expression Resume Examples & Samples

The individual will work as part of the Cell Biology R&D team to support ongoing projects within the Thermo Fisher product commercialization process under the Gibco™ brand with future growth opportunity for independent project leadership
The successful candidate will possess a strong background in mammalian cell culture for transient protein expression, with experience in stable cell line generation and knowledge of GMP regulations/cell banking a plus
Experience with scalable protein expression, from microtiter plates to bioreactors is desirable, as is experience in molecular biology for plasmid generation, amplification and purification
Candidate will play a significant role in generating applications data for Thermo Fisher expression systems and foster customer collaborations
The candidate will be required to maintain accurate lab notebooks and training files in accordance with relevant Thermo Fisher required standards to support patent application and defense as well as other international standards (e.g., ISO compliance, GLP/GMP requirements, etc.)
Typical requirements will include preparing and presenting experimental data summaries and protocol writing
Perform literature searches related to products under development and new idea generation
Work with customers to troubleshoot problems and understand unmet needs
The successful candidate will make contributions to scientific literature and conferences and comply with all company safety regulations and procedures
B.S or M.S. degree with demonstrated background in protein expression and/or other closely related discipline
3-5+ years industry or academic experience
Strong mammalian cell culture skills
Standard molecular biology techniques including DNA cloning, plasmid preparation/purification,
Demonstrated competence completing tasks under direct supervision
Strong verbal and written communication skills and the ability to interpret, summarize, and present scientific results in a clear, concise, accurate manner to both technical and non-technical audiences
Demonstrated ability to achieve results and solve problems
Transient protein expression/transfection a plus
Strong insect or bacterial cell culture a plus
LSG-IND

Protein Expression Scientist Month Fixed Term Contract Resume Examples & Samples

Contributing to the scientific direction of technology development within the Cell Culture and Fermentation Sciences Department
Cell Culture and Cell Biology
Plasmid DNA scale-up and purification for routine transfections
Protein analysis using techniques such as SDS PAGE, western blotting
Experience in mammalian cell culture and protein expression from eukaryotic cells in an industrial or academic environment
Experience in transient expression systems
Experience / knowledge of molecular / cell biology techniques
Experience in analytical techniques such as SDS PAGE and western blotting
Experience with bioreactor systems for mammalian cell culture would be useful but not essential

Protein Design Scientist Resume Examples & Samples

Minimum of a Ph.D. or equivalent in biochemistry, computational biology, molecular biology, structural biology or a related discipline with significant experience in protein design
Working expertise of the experimental and computational aspects of protein structure/function and design
Fluent in Linux and computer programming/scripting
Proficient in tools/algorithms used for computational design/analysis of novel proteins
Excellent communication and interpersonal skills and the ability to work on multiple project teams
1 or more years of Postdoctoral experience or equivalent industry experience
Experience interfacing with computer clusters, preferably cloud based
Comfortable with large, complex datasets and machine learning algorithms
Familiar with wet lab techniques in protein biochemistry
Experience in project collaboration
Relevant scientific publications in peer reviewed journals

Protein Scientist AS Resume Examples & Samples

Contribute to project progression through the cloning, expression and purification of proteins in prokaryotic and eukaryotic systems
Perform protein analysis (e.g. quantification, purity and MW determination, N-terminal sequencing)
Work with project teams to co-ordinate supply of proteins within project timelines
Familiarity with protein purification systems e.g. Akta
Protein analysis by SDS-PAGE, western blot, spectrophotometry
PhD in relevant area or relevant industry experience
Performing molecular biology and biochemistry techniques, such as DNA manipulations, phage display and protein engineering, to achieve project objectives
Running kinetic binding screens e.g. BIAcore, Octet

Senior Protein Chromatography Scientist Resume Examples & Samples

Perform primary analytical techniques (i.e., electrophoretic [SDS PAGE, IEF], HPLC [reverse phase, size exclusion and ion exchange], and plate reader based assays) and document observations, deviations, testing, and results clearly and completely
Read, understand, set-up, validate, and perform analytical procedures
Train, cross-train, and assist others in the laboratory
At least 3 years of experience in Bio/pharmaceutical industry
A strong understanding of instrumentation theory and analytical techniques as applied to Biopharmaceuticals

Protein Conjugation & Purification Scientist Resume Examples & Samples

Synthesis, purification and characterization of ADCs on mg to gram scale under minimal supervision
Optimization and validation of conjugation protocols and formulation buffers
Optimization of automated techniques for ADC synthesis and purification
BS degree with minimum of 5 years of experience or MS degree with minimum of 2 years of experience in Analytical chemistry, Biochemistry, Chemistry or other relevant discipline
Knowledge and experience in laboratory scale protein purification, employing Hydrophobic Interaction Chromatography (HIC), Size Exclusion Chromatography (SEC), Ion-Exchange (IEX), mixed mode chromatography and affinity chromatography
Experience with GE AKTA FPLC and unicorn software preferred
Previous experience in the discovery and development of Antibody-Drug Conjugates, including hands-on experience with the conjugation and purification process is desired
Hands on experience in analytical techniques including HIC-HPLC, SEC, IEX, RP-HPLC, and capillary electrophoresis (e.g. reduced and non-reduced CE-SDS, icIEF)
This position requires an individual who is self-motivated, enthusiastic, hard-working, detail-oriented, with demonstrated problem solving skills who is able to work in a fast-paced team environment
High-quality written and oral communication skills and the ability to excel in a collaborative environment are essential

Scientist, Protein Homeostasis Resume Examples & Samples

Generate testable hypotheses and execute experiments
Document, interpret and troubleshoot results
Communicate with peers and supervisors and foster teamwork
Demonstrate adaptability
Supervise or guide research staff
Extensive wet-lab experience with routine molecular, cellular and genetic biology tools
Extensive experience with Cas9-CRISPR mediated gene editing and genome-wide CRISPR screen
Extensive experience with flow cytometry analysis and FACS
Extensive experience with next generation sequencing(NGS) methods
Comprehensive knowledge of hematological malignancy
Learning the drug development process
Possess in-depth knowledge in area
Responsible for more complex assignments and for more than 1 project

Flpc / Akta Protein Purification Scientist Resume Examples & Samples

Protein purification with FPLC including affinity, ion exchange, HIC, etc
Protein purification from E. Coli, mammalian and/or insect cells
Cell culture maintenance and transfections including: CHO, HEK 293, sf9, and sf21
Molecular cloning including: PCR, DNA digestion, ligation, and mutagenesis
Development and effective application of a broad spectrum of practical laboratory skills; including molecular biology, cell culture, biochemistry, assay development, in depth analysis of bioactivity data and the use of automated equipment
Effectively utilize standard laboratory equipment including hand pipettes, balances, pH meters, plate readers and calculators
Practice preventative maintenance on laboratory equipment and replenish laboratory supplies as stock is depleted to prevent “down-time”
Keep accurate, legible and complete records of all experiments and observations. Record all appropriate data electronically in databases
Communicate orally and in writing unexpected occurrences which could adversely affect established timetables
Bachelors or Master’s Degree with a major in Biology or Biochemistry and at least five years of relevant experience, or equivalent industrial experience
Experience in a laboratory research setting applying knowledge of protein biochemistry, molecular biology and data analysis techniques

Formulations Protein Biophysical Scientist Resume Examples & Samples

Develop and execute biochemical and biophysical assays to support formulation development efforts
Apply computational tools to gain insight on excipient selection
Support mechanistic understanding of formulated products to help refine formulation space
Hands-on work in the lab
Excellent analytical and communication skills, and proven ability to function well in a matrix organization pursuing team objectives

Scientist, Protein Homeostasis Tcoe-san Diego Resume Examples & Samples

Develop and implement relevant cell based assays to support identification, optimization, and validation of novel targets and chemical matter
Design and conduct essential experiments in cell biology, cellular biochemistry, molecular biology, and assay development
Previous hands-on experience with various molecular and cellular technologies including, but not limited to, quantitative PCR, immunofluorescence and manipulation/editing of gene/message/protein via RNAi and/or CRISPR methods is desired. Experience in mammalian cell culture including primary cell culture is required
Ability to work in a fast-paced dynamic team environment; flexibility to adapt to changes with a positive attitude

Scientist, Protein Homeostasis Resume Examples & Samples

Generate testable hypotheses and execute experiments to support biology needs in drug discovery teams
Develop and implement cell-based assays to define SAR of novel chemical matters
Ability to work in a fast-paced dynamic team environment
Flexibility to adapt to changes with a positive attitude
Broad hands-on experience with routine molecular, cellular and genetic biology tools
Extensive experience with Cas9-CRISPR mediated gene editing and lentiviral shRNA-mediated gene silencing
Comprehensive knowledge of cancer biology and protein ubiquitination
Experience with flow cytometry analysis and FACS is desired
Experience in Next Generation Sequencing is preferred but not required

Principal Scientist, Protein Homeostasis Resume Examples & Samples

Collaborate with translational and discovery biologists, computational biologists, and clinicians to bring a systems biology understanding to in vivo drug mechanisms and disease biology
Define testable hypotheses and recommendations on dose and schedule, combinations, and subsets to optimize efficacy and patient outcomes
Design experiments to test hypotheses from clinical observations in preclinical model systems
Work across geographies and scientific domains
Analyze clinical and preclinical data to increase understanding of in vivo exposures, associated pathway modulations in different tissues and cells, and systems-level consequences for both efficacy and toxicity
Key point of contact and collaboration with computational biology group
Define data that will increase understanding of drug action at the systems level, and strategies to acquire it
Interact with project teams, academic collaborators and contract laboratories to design in vitro and in vivo studies to evaluate drug candidates
Potentially mentor other research staff through instruction, coaching and guidance
Systems biology training and ability to use this perspective to inform development strategy
Expert in the acquisition and interpretation of NGS, omic, and other analysis methods that generate high-dimensional data
Knowledge of cancer biology and drug development
Proven ability to derive novel insights from complex data
Ability to interpret and summarize scientific data in an accurate, critical and concise manner
Experienced in the integration of preclinical research through to clinical drug development
Highly effective teamwork and interpersonal skills
Exceptional written and verbal communications skills
Systems biology expert
Expert in the systems interpretation of NGS, omic, and other analysis methods that generate high-dimensional data
Knowledge of cancer biology and pathways

Membrane Protein Structural Scientist Resume Examples & Samples

The successful candidate will perform crystallization screening, crystal optimization, and structure determination of ligand complexes and will work in collaboration with medicinal and computational chemists
Work closely with molecular biologists and protein biochemists and will have access to automated cloning, expression, and crystallization technologies as well as a variety of instrumentation for biophysical analyses
Productive and collaborative interactions with other members of the global, cross-functional department
Cooperative and collaborative use of internal expertise and resources will be essential to success
The position requires active interaction with the external scientific community to continually improve scientific understanding, including presentations at national or international meetings
Support drug lead discovery and optimization through the determination of X-ray structures of therapeutically important targets with a focus on membrane proteins
Perform crystallization, crystal optimization, and structure determination of protein-ligand complexes to drive structure-based drug discovery
Productive and collaborative interactions with other members of the cross-functional department, including medicinal and computational chemists, biochemists, and molecular biologists. Cooperative and collaborative use of internal expertise will be essential to success
Active interaction with the scientific community to continually improve scientific understanding, including presentations at national or international meetings and publication in peer-reviewed journals
Active participation in recruitment, training and development of scientific staff
Periodic travel to other locations will be required
Required: Ph.D. degree with a minimum of (8) years experience in Membrane Protein Structure Determination
Minimum of (8) years experience in the application of Structural Biology to Industrial Drug Discovery
Proven track record in the use of state-of-the-art membrane protein structural biology techniques, including all aspects of construct design and screening, expression in mammalian and insect cell lines, purification, crystallization (including bicelles, LCP), and structure determination/analysis
Demonstrated capability to design and execute X-ray crystallographic structure determination using all modern techniques, including molecular replacement and experimental phasing
Experience with biophysical characterization methods (e.g. protein NMR, Biacore, Thermoflor) or functional properties (e.g. ligand binding, electrophysiology, and receptor modality)
Strong publication record in the field of membrane protein structural biology
Evidence of leadership in the training and mentoring of team members and project management
Strong communication skills that enhance team-based progress. Application of those skills both within and outside the department to ensure the maximum understanding of program status for therapeutic area project teams and management
Ability to work effectively within timelines
Experience with cryo-EM techniques
Experience in overseeing the work of other PhD level scientists

Scientist, Protein Homeostasis Resume Examples & Samples

Develop and implement relevant cell based assays to support identification, optimization, and characterization of novel chemical matter and their targets
Design and conduct essential experiments in cell biology, molecular biology, protein biochemistry and assay development with a strong commitment to quality and reproducibility
Ph.D. with at least 4 years of post-doctoral experience in molecular and cell biology with in-depth knowledge and training in cancer and immune cell biology
Previous hands-on experience with various molecular and cellular technologies including, but not limited to, QPCR, immunofluorescence and manipulation/editing of gene/message/protein via CRISPR and/or lentiviral shRNA methods is preferred
Experience in mammalian cell culture, including primary cell and cell line co-culture assays, and/or 3D tumor models is desired
Excellent communication, presentation, collaboration and organizational skills are required
Capability to stay focused and deliver high quality data in a timely and well organized manner
Ability to enjoy working in a fast-paced dynamic team environment with the flexibility to adapt to changes with a positive attitude
Acts as a liaison between Project Team and functional area
Provide scientific direction
Potential to manage and/or coordinates workflow on projects
Align science and functional area goals with business strategies

Protein Scientist AS, / SCI Resume Examples & Samples

Perform additional molecular biology tasks (e.g. cloning, phage display selections) as and when required by the project
Analyse results and compile data summaries for project meetings, patents and publications
Communicate results, conclusions and recommendations to colleagues, at team meetings and to external collaborators
Degree in Life Sciences
Protein expression and purification in both prokaryotic and eukaryotic systems
Knowledge of DNA sequence analysis software, including oligonucleotide and construct design
Ability to work aseptically in tissue culture
Advanced protein analysis e.g. Mass Spectrometry for N-terminal sequencing
Protein conjugation experience e.g. biotinylation of proteins

Scientist, Protein Purification Resume Examples & Samples

Responsible for manufacturing product(s) in a lab setting following standard operating procedures. Will utilize basic laboratory techniques, calculations, materials measurement, operation of laboratory equipment and record keeping necessary to manufacture products
Write technical documents which may include standard operating procedures and batch records
Must have a Bachelor s degree (BS) in Biology, Chemistry, Biochemistry, or other related discipline. Master's degree (MS) is a plus
Requires a minimum of three (3) years relevant experience demonstrating laboratory techniques in a manufacturing environment or research laboratory
Familiar with GE AKTA FPLC protein chromatography equipment and Unicorn software
Experience with different modes of chromatography such as: affinity, ion-exchange, size exclusion, hydrophobic interaction
Assessment of purified kinases through radioactive activity, fluorometric plate based assays, and TR-FRET
May be required to stand for long periods of time while performing duties
Must be flexible to work varying schedules and hours as needed
Must be able to work safely with chemicals and hazardous materials
Follows and provides direction accurately and efficiently
Good communication skills, both written and verbal

Senior Scientist, Protein Science Resume Examples & Samples

Contributes to project strategy and planning and may lead a small team in pursuit of the development of scalable purification processes for recombinant protein therapeutics
Leads comprehensive data analysis of process statistics independently, identify process deviations, prepare technical reports and propose comprehensive process solutions and improvements
Participates in training and development opportunities in order to gain an understanding of standards of practice, process science and departmental policies. Provide comprehensive training and guidance to more junior scientists
Develops technical solutions to downstream CMC problems independently and proactively exchanges technical information with team members within Process Science and with cross functional group for troubleshooting and ongoing supports
Leads in project planning and execution including evaluation of equipment and implementation of appropriate modifications and staff training to ensure employee safety. Schedules process equipment used in process science labs and ensure equipment is maintained per preventative maintenance schedule
Has regular direct communications with external and internal customers to ensure processes and methods meet specifications and requirements and supports scale-up and transfer of processes to our large scale manufacturing plants including trouble shooting
Assists in continuous improvement in innovation and technology and contributes a stronger IP position for BI. This position will support establishing state-of-the-art technologies for process development
May lead or support drug product studies leading to transfer of the process to clinical or commercial manufacturing
Good statistical analysis skills
Experience in DOE and process characterization
Experience in authoring regulatory filing documents
Knowledge in protein analytics including spectrophotometry, HPLC, CE, and mass spec

Principal Scientist, Protein Purification Resume Examples & Samples

Up-to-date on advanced technologies for downstream processing and actively apply new concepts as appropriate to continuously improve functional area capabilities
Ability to manage multiple projects simultaneously and multitask
Experience in the pharmaceutical or biotechnology industry

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