Scientist II- Brain Targeting
Job Details
Position Description
What you'll do:
- Support in vitro and in vivo validation of brain shuttles, using protein and cell binding assays, and in vivo brain and blood pharmacokinetics and pharmacodynamic (PK/PD) studies in mouse models.
- Lead brain shuttle-mediated ASO delivery platform development.
- Choose and adapt ASO production approaches from the public domain and prepare material either in-house or with a CRO.
- Perform conjugation of ASOs with antibody shuttles, with traditional or novel conjugation chemisty(ies).
- Design mouse studies for shuttle-ASO validation; prepare and analyze mouse tissues and blood for PK/PD analysis.
- Select appropriate mouse disease models and validate novel shuttle-ASO fusion drugs in models of Alzheimer’s disease, Parkinson’s disease, ALS and others.
- Develop, validate, and perform various protocols including confocal microscopy, flow cytometry, cell-based assays, plate-based ELISA assays, and others.
- Analyze and interpret experimental data, learn new skills, troubleshoot, and contribute intellectually to projects.
- Present data and results at meetings internally and externally.
- Perform support activities and lab maintenance as assigned, and function in a team-oriented environment with other scientists and staff at the Institute as well as external collaborators.
- Supervise and train junior scientists, academic trainees, and others
- Demonstrates a commitment to diversity, inclusion, and cultural awareness through actions, interactions, and communications with others
Basic Qualifications
What you'll need:
- Bachelor’s degree in neuroscience, biology, molecular biology, biochemistry, or related field.
- A minimum of 5 years of experience with ASO chemistry and conjugation, cell culture, rodent handling, and molecular and cellular biology techniques such as ELISA, western blotting, confocal imaging, fluorescence-activated cell sorting (FACS), or related experience. Advanced education may count towards years of experience.
Additional Qualifications and Skills
Desirable skills:
- PhD in neuroscience, biology, molecular biology, biochemistry, or related fields strongly preferred.
- Industry experience preferred.
- Experience with ASO conjugation, including development and optimization of conjugation protocols.
- Ability to work independently as well as to collaborate with a multidisciplinary group.
- Commitment for diversity, inclusion and cultural awareness through actions, interactions, and communications with others.
Additional Information
Offer contingent on successful completion of pre-placement medical evaluation
Why you’ll like working with us:
At the Wyss Institute, you’re a member of a supportive, dynamic community that is united by its shared goal of changing the world through groundbreaking technology development and commercialization. We encourage your professional growth and development through mentorship and tuition reimbursement to support continued learning, and more. We also support your physical, financial, and mental well-being through generous time off benefits, gym reimbursements, and other programs offered through Harvard. Our facility is located in a new, state-of-the-art life sciences building in the lively Fenway neighborhood, where you have access to multiple amenities including a roof top terrace with stunning views of Boston and proximity to numerous restaurants and cultural attractions. We value an inclusive and diverse workforce, and believe that our differences enrich the work environment for all.
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