Scientist, Biologics Cover Letter

Please consider me for the scientist, biologics opportunity. I am including my resume that lists my qualifications and experience.

Previously, I was responsible for process development oversight and upstream and downstream technical support/troubleshooting for Engineering and cGMP runs.

Please consider my qualifications and experience:

• Highly motivated, self-driven and results-oriented with excellent written and oral communication and presentation skills
• English language proficiency is essential
• Experience with statistical analyses and design of experiments are an advantage
• Demonstrated expertise across a wide range of cellular and biochemical assays such as primary cell work, flow cytometry, ELISA and molecular biology
• Experience with assay development and validation would be advantageous
• Experience in standard molecular biology and protein biochemistry techniques
• Experience with working in a BSL 2 environment is an asset
• Working knowledge of various data analysis and visualization tools (JMP, Spotfire ) is desirable

In response to your job posting for scientist, biologics, I am including this letter and my resume for your review.

In the previous role, I was responsible for process oversight and upstream and downstream technical support/troubleshooting for Engineering and cGMP runs.

Please consider my experience and qualifications for this position:

• Technically skilled in single cell PCR, B-cell culture, FACS sorting, cell-based assay development
• A strong publications record highly preferred3660170616
• Proven track record in scientific excellence, data review and interpretation
• Work as part of a multidisciplinary team, actively participate in- and guide discussions, negotiate prioritie
• Very good knowledge of English (oral and written)
• Excellent organizational skills with respect to planning, tracking, priority setting and adherence to project timelines
• Excellent communication, presentation and scientific/technical writing skills
• BS/MS in pharmacology, biology

I am excited to be applying for the position of scientist, biologics. Please accept this letter and the attached resume as my interest in this position.

In my previous role, I was responsible for technical oversight of formulation and analytical development activities of biologic drug products, such as compatibility studies, formulation screening, supportive stability, analytical testing, method development, and method optimization.

Please consider my qualifications and experience:

• Experience with immunochemical, chromatography-based, and/or cell-based analytical methods
• Demonstrated expertise in protein or nucleic acid purification using a variety of methods and systems (AKTA) such as membrane based purifications and chromatographic methods like ion exchange, SEC, HIC, and hydroxyapatite
• Experience with analytical methods (HPLC, UV-Vis, ELISA, MALS) to characterize purified proteins or nucleic acids
• Experience in making and characterizing protein or nucleic acid delivery vehicles such as lipid nanoparticles, polymers, or targeting ligands
• Experience with sample tracking / data base management beneficial
• Hands-on experience with mammalian cell culture, transfection, and stable line selection
• Hands-on experience with vector construction and routine DNA cloning
• Experience with high throughput screening assays such as Octet,ELISA, and FACS analysis

I would like to submit my application for the scientist, biologics opening. Please accept this letter and the attached resume.

In the previous role, I was responsible for technical support to internal and external cGMP analytical operations.

I reviewed the requirements of the job opening and I believe my candidacy is an excellent fit for this position. Some of the key requirements that I have extensive experience with include:

• Proficient in data analysis and common computer applications
• Be able to work independently and in a fast paced environment to meet project timelines
• Develop and optimize cell based assays for transfection of nucleic acid constructs (mRNA, antisense, CRISPR, DNA, AAV...) using lipid and polymer based formulations in multiple cell lines and using molecular biology techniques such as Luminescence/Fluorescence based assays and ELISA, cytotoxicity and cell proliferation assays
• Perform formulation optimization for nucleic acid delivery and assist in biophysical characterizations such as particle size analysis, zeta potential and encapsulation using instruments such as Malvern ZetaSizer and gel based imaging
• Assist in planning and delivery of nucleic acids formulations for in vivo studies
• Master of Science in Biochemistry, Biotechnology, Bioengineering or equivalent with focus on mammalian expression or equivalent education/experience
• Interest in broadening area of expertise (parallel fermentation, media preparation and logistics, pilot scale batches)
• Expertise in areas of cellular and molecular biology, expression in mammalian systems, protein characterization, assay development and animal models

I am excited to be applying for the position of scientist, biologics. Please accept this letter and the attached resume as my interest in this position.

Previously, I was responsible for training and support to Product Development personnel during the development and scale up of formulations on cGMP equipment.

Please consider my experience and qualifications for this position:

• Experience w/ design, planning, execution and interpretation of immunoassays for the evaluation of pharmacokinetics and immunogenicity of biologics
• Advanced laboratory bench skills such as ELISAs, Western blots, qPCR or FACS
• Detailed knowledge of Excel, Word, Powerpoint and Graphpad prism
• PhD or equivalent in Biochemistry or related field with min
• Experience in SPE, Immunoassy, and sample preparation automation for Biologics
• Demonstrated experience in LC/MS of mAbs, proteins and peptide digests
• An aptitude for modification of equipment or instruments to meet study goals
• Experience in managing or supervising staff researchers and technicians